Cuddy Thomas Edward, Halli Priyanka S, Tate Robert B
Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Prev Cardiol. 2009 Winter;12(1):27-33. doi: 10.1111/j.1751-7141.2008.00016.x.
As many as half of all sudden cardiac deaths are unexpected, with no preceding symptoms or signs of cardiac problems. Since 1948, the Manitoba Follow-up Study has prospectively recorded routine medical information and resting electrocardiographic (ECG) findings from a cohort of 3983 men. During 58 years of follow-up, 180 men experienced sudden unexpected cardiac death (SUCD). Heart rate, the longest QT interval, the shortest QT interval, and their difference and QT dispersion (QTD) on ECGs recorded prior to SUCD and 5 years and 10 years earlier were compared with QT intervals on ECGs of age-matched controls. QTD and heart rate each were significantly (P < .01) and independently associated with increased risk for SUCD. Only primary prevention can reduce the risk for SUCD. Hence, this relationship between QTD and heart rate and SUCD emphasizes the importance of longitudinal noninvasive QT measurements on routine ECGs in healthy men.
多达一半的心脏性猝死是意外发生的，之前没有心脏问题的症状或体征。自1948年以来，曼尼托巴随访研究前瞻性地记录了3983名男性队列的常规医疗信息和静息心电图（ECG）结果。在58年的随访期间，180名男性经历了意外心脏性猝死（SUCD）。将SUCD发生前、5年前和10年前记录的心电图上的心率、最长QT间期、最短QT间期及其差值和QT离散度（QTD）与年龄匹配对照组的心电图QT间期进行比较。QTD和心率均与SUCD风险增加显著相关（P <.01）且独立相关。只有一级预防才能降低SUCD的风险。因此，QTD、心率与SUCD之间的这种关系强调了对健康男性常规心电图进行纵向无创QT测量的重要性。
