在恶性间皮瘤中，血清间皮素比透明质酸具有更高的诊断效用。
Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma.
作者信息
Grigoriu Bogdan, Chahine Bachar, Zerimech Farid, Grégoire Marc, Balduyck Malika, Copin Marie-Christine, Devos Patrick, Lassalle Philippe, Scherpereel Arnaud
机构信息
INSERM Unit 774, Institut Pasteur de Lille, Rue du Professeur Calmette, 59000 Lille, France.
出版信息
Clin Biochem. 2009 Jul;42(10-11):1046-50. doi: 10.1016/j.clinbiochem.2009.03.007. Epub 2009 Mar 18.
UNLABELLED
We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin.
MATERIALS AND METHOD
We measured serum and pleural fluid values of mesothelin and hyaluronic acid in 76 patients with MPM, 33 patients with pleural metastases of carcinomas (Mets group) and 27 patients with benign pleural effusion related to asbestos exposure (BPLAE).
RESULTS
Using a serum HA cut-off of 100 microg/L, 8 patients/33 (24.2%) were positive in the Mets group versus 20/76 (26.3%) in the MPM group and only 1/27 BPLAE patients. The area under ROC curve for serum HA in MPM versus Mets or BPLAE groups was only 0.617 while it was 0.755 for mesothelin. In pleural fluid, both markers had similar diagnostic values.
CONCLUSIONS
Serum mesothelin is more sensitive than hyaluronic acid in diagnosing MPM and there is no benefit in combining both markers.
未标注
我们比较评估了两种潜在的恶性胸膜间皮瘤（MPM）标志物：透明质酸（HA）和可溶性间皮素的诊断价值。
材料与方法
我们测量了76例MPM患者、33例癌性胸膜转移患者（转移组）和27例与石棉暴露相关的良性胸腔积液患者（BPLAE）的血清和胸腔积液中间皮素和透明质酸的值。
结果
血清HA临界值为100μg/L时，转移组33例中有8例（24.2%）呈阳性，MPM组76例中有20例（26.3%）呈阳性，而BPLAE组27例中仅有1例呈阳性。MPM组与转移组或BPLAE组相比，血清HA的ROC曲线下面积仅为0.617，而间皮素为0.755。在胸腔积液中，两种标志物具有相似的诊断价值。
结论
血清间皮素在诊断MPM方面比透明质酸更敏感，联合使用这两种标志物并无益处。
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