HLA - DPB1*0301是类风湿因子阴性的成年类风湿关节炎的主要危险因素。

HLA-DPB1*0301 is a major risk factor for rheumatoid factor-negative adult rheumatoid arthritis.

作者信息

Gao X, Fernandez-Viña M, Olsen N J, Pincus T, Stastny P

机构信息

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8886.

出版信息

Arthritis Rheum. 1991 Oct;34(10):1310-2. doi: 10.1002/art.1780341016.

DOI:10.1002/art.1780341016

PMID:1930320

Abstract

HLA-DPB1 alleles were determined using the polymerase chain reaction and allele-specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB10301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P less than 0.0001). With our previous finding that DPB10301 is increased in seronegative children with polyarticular-onset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.

摘要

使用聚合酶链反应和等位基因特异性寡核苷酸探针，对高加索类风湿性关节炎（RA）患者和健康对照者进行HLA - DPB1等位基因测定。发现血清阴性患者中DPB10301增加（50.0%，而对照组为10.8%；相对风险=8.3，P<0.0001）。鉴于我们之前发现多关节起病的血清阴性儿童中DPB10301增加，这些结果提示该疾病与成人血清阴性RA之间存在关联。