Gastmeier P, Weitzel-Kage D, Behnke M, Eckmanns T
Institute of Hygiene and Environmental Medicine, Charité University Medicine, Hindenburgdamm 27, D-12203 Berlin, Germany.
Int J Antimicrob Agents. 2009 Mar;33 Suppl 1:S19-23. doi: 10.1016/S0924-8579(09)70011-1.
A study of 2856 Clostridium difficile -associated diarrhoea (CDAD) patients from 34 hospitals in Germany was carried out over a period of 12 months in 2007. The overall incidence of CDAD cases was 46.5 per 10,000 admitted patients, or 6.6 cases per 10,000 patient-days. Seventy-three percent of cases were considered to be nosocomial and 8.4% were classified as severe. There was a wide range in the incidence of CDAD between the hospitals (interquartile range [IQR] 3.2-9.2 cases per 10,000 patient-days), and the incidence of nosocomial cases (IQR 1.7-6.7 per 10,000 patient-days). The differences between the hospitals were in line with the differences in local diagnostic and infection control procedures. The overall incidence in the hospitals participating in the surveillance system was much higher than that in the discharge data from the whole of Germany in 2006. This may be due to more diligent ICD9 coding by the clinicians during an active surveillance strategy. However, the group of hospitals participating in the study was small and may not be representative of the situation in the country as a whole.
2007年，在12个月的时间里，对德国34家医院的2856例艰难梭菌相关性腹泻（CDAD）患者进行了一项研究。CDAD病例的总体发病率为每10000名入院患者中有46.5例，即每10000个患者日中有6.6例。73%的病例被认为是医院感染性的，8.4%被归类为严重病例。各医院之间CDAD的发病率差异很大（四分位间距[IQR]为每10000个患者日3.2 - 9.2例），医院感染病例的发病率差异也很大（IQR为每10000个患者日1.7 - 6.7例）。各医院之间的差异与当地诊断和感染控制程序的差异一致。参与监测系统的医院的总体发病率远高于2006年德国全国出院数据中的发病率。这可能是由于在积极监测策略期间临床医生对ICD9编码更加勤勉。然而，参与研究的医院群体规模较小，可能无法代表整个国家的情况。
