Dumas Eve-Marei, Ozenne Valéry, Mielke Randall E, Nadeau Jay L
Department of Biomedical Engineering, McGill University, Montreal, QC H3A2B4, Canada.
IEEE Trans Nanobioscience. 2009 Mar;8(1):58-64. doi: 10.1109/TNB.2009.2017313. Epub 2009 Mar 16.
Contradictory results on quantum dot cytotoxicity exist for many types of biological systems, especially microorganisms. In this study, we compare the cytotoxicity of CdTe quantum dots (QDs) to four very different environmental bacterial strains, giving quantitative models of the growth curves for exposed organisms. The mechanisms of toxicity are explored by measuring reactive oxygen species generation by the QDs alone and investigating the oxidative damage to mutant bacteria especially sensitive to ROS. Electron microscopic examination also reveals factors that may contribute to resistance to nanoparticles in some strains.
对于许多类型的生物系统，尤其是微生物，关于量子点细胞毒性的结果相互矛盾。在本研究中，我们比较了碲化镉量子点（QDs）对四种截然不同的环境细菌菌株的细胞毒性，给出了暴露生物体生长曲线的定量模型。通过单独测量量子点产生的活性氧物种以及研究对活性氧特别敏感的突变细菌的氧化损伤来探索毒性机制。电子显微镜检查还揭示了某些菌株中可能有助于抵抗纳米颗粒的因素。
