Ligresti Giovanni, Militello Loredana, Steelman Linda S, Cavallaro Andrea, Basile Francesco, Nicoletti Ferdinando, Stivala Franca, McCubrey James A, Libra Massimo
Department of Biomedical Sciences, University of Catania, Catania, Italy.
Cell Cycle. 2009 May 1;8(9):1352-8. doi: 10.4161/cc.8.9.8255. Epub 2009 May 23.
Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110alpha subunit of PI3K (PIK3CA) have been identified in a broad spectrum of tumors. Analyses of PIK3CA mutations reveals that they increase the PI3K signal, stimulate downstream Akt signaling, promote growth factor-independent growth and increase cell invasion and metastasis. In this review, we analyze the contribution of the PIK3CA mutations in cancer, and their possible implications for diagnosis and therapy.
磷脂酰肌醇3-激酶（PI3Ks）是一类脂质激酶，可调节参与细胞增殖、黏附、存活和运动的信号通路。PI3K信号通路被认为在肿瘤发生中起重要作用。在多种肿瘤中已鉴定出PI3K的p110α亚基（PIK3CA）的激活突变。对PIK3CA突变的分析表明，它们增强了PI3K信号，刺激下游Akt信号传导，促进不依赖生长因子的生长，并增加细胞侵袭和转移。在本综述中，我们分析了PIK3CA突变在癌症中的作用及其对诊断和治疗的潜在影响。
