Kumar Amit, Carrera Ana C
Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Cell Cycle. 2007 Jul 15;6(14):1696-8. doi: 10.4161/cc.6.14.4492. Epub 2007 May 25.
Although cell lipids were initially envisioned as structural components of the cell, their essential contribution to initiation and regulation of cell responses is now clearly established. Among the different lipids that regulate cell responses, those produced by class I phosphoinositide 3-kinase (PI3K), phosphatidylinositol (3,4)P(2) (PIP(2)) and phosphatidylinositol (3,4,5)P(3) (PIP(3)), have concentrated much attention in recent years. PIP(2) and PIP(3) are involved in cell division and survival control, and mutations in the PI3K pathway are linked to autoimmunity and cancer. Here we discuss two novel observations: a PI3K function in the late-G(1) phase of the cell cycle and the contribution of the p85 PI3K regulatory subunit in the control of cytokinesis.
尽管细胞脂质最初被认为是细胞的结构成分，但它们对细胞反应的起始和调节的重要贡献现已明确确立。在调节细胞反应的不同脂质中，由I类磷酸肌醇3-激酶（PI3K）产生的那些脂质，磷脂酰肌醇（3,4）二磷酸（PIP(2)）和磷脂酰肌醇（3,4,5）三磷酸（PIP(3)），近年来备受关注。PIP(2)和PIP(3)参与细胞分裂和存活控制，并且PI3K途径中的突变与自身免疫和癌症相关。在这里，我们讨论两个新的发现：PI3K在细胞周期G(1)晚期的功能以及p85 PI3K调节亚基在胞质分裂控制中的作用。
