β-连环蛋白作用于染色质：Wnt靶基因激活的调控
Beta-catenin hits chromatin: regulation of Wnt target gene activation.
作者信息
Mosimann Christian, Hausmann George, Basler Konrad
机构信息
National Research Center Frontiers in Genetics, Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
出版信息
Nat Rev Mol Cell Biol. 2009 Apr;10(4):276-86. doi: 10.1038/nrm2654.
The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear beta-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that beta-catenin-mediated transcription affects chromatin. How does beta-catenin cope with chromatin regulation to turn on Wnt target genes?
近年来，经典Wnt信号通路因其在后生动物发育、组织稳态和人类恶性肿瘤中的重要作用而备受关注。Wnt靶基因的转录受细胞核内β-连环蛋白调控，遗传学分析已揭示了多种协同作用的蛋白质辅因子。然而，其数量之多、性质之多样，使得难以梳理出细胞核内Wnt转导事件的有序图景。不过，这些发现强调了β-连环蛋白介导的转录会影响染色质。β-连环蛋白如何应对染色质调控以开启Wnt靶基因呢？
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