欧洲癌症与营养前瞻性调查（EPIC）中来自七个国家的636名中年男性的生活方式因素与血清雄激素水平

Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC).

作者信息

Suzuki Reiko, Allen Naomi E, Appleby Paul N, Key Timothy J, Dossus Laure, Tjønneland Anne, Føns Johnsen Nina, Overvad Kim, Sacerdote Carlotta, Palli Domenico, Krogh Vittorio, Tumino Rosario, Rohrmann Sabine, Linseisen Jakob, Boeing Heiner, Trichopoulou Antonia, Makrygiannis Georgios, Misirli Gesthimani, Bueno-de-Mesquita H Bas, May Anne M, Díaz María José Tormo, Sánchez Maria-José, Barricarte Gurrea Aurelio, Rodríguez Suárez Laudina, Buckland Genevieve, Larrañaga Nerea, Bingham Sheila, Khaw Kay-Tee, Rinaldi Sabina, Slimani Nadia, Jenab Mazda, Riboli Elio, Kaaks Rudolf

机构信息

Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

出版信息

Cancer Causes Control. 2009 Aug;20(6):811-21. doi: 10.1007/s10552-009-9326-y. Epub 2009 Mar 21.

DOI:10.1007/s10552-009-9326-y

PMID:19306067

Abstract

OBJECTIVE

To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men.

METHODS

We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione (A-dione), 3-alpha-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone (FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition.

RESULTS

Compared with the youngest age group (40-49 years), the oldest (70-79 years) had a higher mean concentration of SHBG (by 44%) and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (> or =29.83 kg/m(2)) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the lowest (<24.16 kg/m(2)). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers. Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest.

CONCLUSION

Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations in men.

摘要

目的

评估中年健康男性的生活方式和饮食因素与雄激素血清浓度之间的关联。

方法

我们对欧洲癌症与营养前瞻性调查中636名男性的生活方式因素与循环中的雄烯二酮（A-dione）、3-α-雄烷二醇葡萄糖醛酸苷（A-diol-g）、睾酮（T）、性激素结合球蛋白（SHBG）和游离睾酮（FT）浓度之间的关联进行了横断面分析。

结果

与最年轻年龄组（40 - 49岁）相比，最年长组（70 - 79岁）的SHBG平均浓度更高（高44%），而A-diol-g（低29%）和FT（低19%）的平均浓度更低。与BMI最低组（<24.16 kg/m²）相比，BMI最高组（≥29.83 kg/m²）的A-diol-g平均浓度更高（高38%），而T（低20%）和SHBG（低29%）的平均浓度更低。与从不吸烟者相比，当前吸烟者的T（高13%）、SHBG（高14%）和A-dione（高15%）平均浓度更高。身体活动和饮食因素与雄激素浓度无关，不过酒精摄入量处于最高五分位数的男性与最低五分位数者相比，A-dione（高9%）和FT（高11%）的平均浓度更高。