Dobretsov Sergey, Teplitski Max, Paul Valerie
Department of Marine Science and Fisheries, Sultan Qaboos University, Sultanate of Oman.
Biofouling. 2009;25(5):413-27. doi: 10.1080/08927010902853516.
Bacterial quorum sensing (QS) is a cell-cell communication and gene regulatory mechanism that allows bacteria to coordinate swarming, biofilm formation, stress resistance, and production of toxins and secondary metabolites in response to threshold concentrations of QS signals that accumulate within a diffusion-limited environment. This review focuses on the role of QS signaling and QS inhibition in marine bacteria by compounds derived from marine organisms. Since the formation of a biofilm is considered to be an initial step in the development of fouling, direct and indirect effects of QS signals and inhibitors on the process of marine biofouling are discussed. Directions for future investigations and QS-related biotechnological applications are highlighted.
细菌群体感应（QS）是一种细胞间通讯和基因调控机制，它使细菌能够在扩散受限的环境中积累的群体感应信号达到阈值浓度时，协调群体游动、生物膜形成、抗逆性以及毒素和次生代谢产物的产生。本综述聚焦于海洋生物来源的化合物在海洋细菌中群体感应信号传导和群体感应抑制方面的作用。由于生物膜的形成被认为是污损发展的初始步骤，因此讨论了群体感应信号和抑制剂对海洋生物污损过程的直接和间接影响。突出了未来研究方向和与群体感应相关的生物技术应用。
