Hohagen F, Lis S, Riemann D, Krieger S, Meyer C, Montero R F, Grunze H, Berger M
Psychiatric Department, University of Freiburg, Germany.
Neuropsychopharmacology. 1994 Aug;11(1):29-32. doi: 10.1038/npp.1994.33.
Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the M1 receptor subtype, and bornaprine, 4 mg, a nonselective M1 and M2 antagonist, were administered orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on polysomnographically recorded sleep. Both drugs suppressed rapid eye movement (REM) sleep as reflected by an increase of REM latency and a decrease in the percentage of REM sleep period time with the effects of biperiden being more pronounced. No significant effect on slow wave sleep was observed. The results of this study support the hypothesis that both the M1 and the M2 receptor subtype are involved in the regulation of REM sleep in humans.
4毫克的比哌立登（一种对M1受体亚型具有相对选择性的抗胆碱能药物）和4毫克的苯乃嗪（一种非选择性M1和M2拮抗剂），以随机、双盲设计口服给予12名健康志愿者，以研究对多导睡眠图记录的睡眠的影响。两种药物均抑制快速眼动（REM）睡眠，表现为REM潜伏期延长和REM睡眠时间百分比降低，比哌立登的作用更为明显。未观察到对慢波睡眠有显著影响。本研究结果支持以下假设：M1和M2受体亚型均参与人类REM睡眠的调节。
