Faulk W P, Labarrere C A
Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.
Am J Reprod Immunol. 1991 Apr;25(3):99-104. doi: 10.1111/j.1600-0897.1991.tb01074.x.
Cryostat sections of human normal term placentae were studied for evidence of immunopathology by using antibodies to lymphocytes, macrophages, platelets, and coagulation factors. Areas of so-called chronic villitis of unestablished etiology were identified in all placentae. The same tissues were examined for HIV protein antigens gp120, p17, p24, and gp41. No evidence for gp41 was found. Antigens gp120 and p17 were identified in normal chorionic villi in vimentin-positive fibroblast-like cells and in endothelium, respectively. Antigen p24 was localized to HLA-DR positive cells that morphologically resembled macrophages in areas of villitis. The distribution of gp120 and p17 was similar to that observed for tissue factor. These findings prompted speculation that retroviral proto-oncogenes that are known to encode for certain placental receptors could be involved in the presentation of tissue factor, and that gp120 may be a hitherto unrecognized immunobiological mechanism for the blockade of CD4 on maternal lymphocytes if and when such cells gain entrance to chorionic villi.
利用针对淋巴细胞、巨噬细胞、血小板和凝血因子的抗体，对人类足月正常胎盘的冷冻切片进行免疫病理学证据研究。在所有胎盘中均发现了病因未明的所谓慢性绒毛炎区域。对相同组织检测HIV蛋白抗原gp120、p17、p24和gp41。未发现gp41的证据。抗原gp120和p17分别在波形蛋白阳性的成纤维细胞样细胞和内皮细胞的正常绒毛膜绒毛中被识别。抗原p24定位于绒毛炎区域中形态上类似于巨噬细胞的HLA-DR阳性细胞。gp120和p17的分布与组织因子的分布相似。这些发现促使人们推测，已知编码某些胎盘受体的逆转录病毒原癌基因可能参与组织因子的呈递，并且如果母体淋巴细胞进入绒毛膜绒毛，gp120可能是一种迄今未被认识的免疫生物学机制，用于阻断母体淋巴细胞上的CD4。
