Møller S, Jensen M, Svensson P, Skakkebaek N E
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
Burns. 1991 Aug;17(4):279-81. doi: 10.1016/0305-4179(91)90039-j.
Variations in growth factor IGF-1 levels during wound healing were assessed in 23 patients with burns of varying extent and severity. The patients were followed during the postburn period and the IGF-1 levels were regularly measured by radioimmunoassay. All patients with large burns had reduced IGF-1 levels which correlated with the surface area of burn. The most plausible reason for the suppressed IGF-1 level in these patients may be diffusion from the burned skin as we have found a strong correlation between IGF-1 and serum albumin. The reduced IGF-1 levels may contribute to impaired wound healing in these patients.
对23例不同程度和严重性烧伤患者在伤口愈合期间生长因子IGF-1水平的变化进行了评估。在烧伤后期间对患者进行随访，并通过放射免疫测定法定期测量IGF-1水平。所有大面积烧伤患者的IGF-1水平均降低，且与烧伤表面积相关。这些患者IGF-1水平受抑制的最合理原因可能是从烧伤皮肤扩散，因为我们发现IGF-1与血清白蛋白之间存在很强的相关性。IGF-1水平降低可能导致这些患者伤口愈合受损。
