Ching Yiu-Hei, Sutton Thomas L, Pierpont Yvonne N, Robson Martin C, Payne Wyatt G
Eplasty. 2011;11:e41. Epub 2011 Nov 7.
Certain cytokines, especially those known as growth factors, have been demonstrated to mediate or modulate burn wound healing. Experimental and clinical evidence suggests that there are therapeutic advantages to the wound healing process when these agents are utilized. Positive effects have been reported for 4 types of wounds seen in the burn patient: partial-thickness wounds, full-thickness wounds, interstices of meshed skin grafts, and skin graft donor sites.
A comprehensive literature search was performed using the MEDLINE, Ovid, and Web of Science databases to identify pertinent articles regarding growth factors and other cytokines in burns and wound healing.
The current knowledge about cytokine growth factors and their potential therapeutic applications in burn wound healing are discussed and reviewed.
Platelet-derived growth factor, fibroblast growth factors, epidermal growth factors, transforming growth factor alpha, vascular endothelial growth factor, insulin-like growth factor I, nerve growth factor, transforming growth factor beta, granulocyte-macrophage colony-stimulating factor, and amnion-derived cellular cytokine solution have all been suggested to enhance the rate and quality of healing in 1 or more of these wounds encountered in burn care.
某些细胞因子，尤其是那些被称为生长因子的细胞因子，已被证明可介导或调节烧伤创面愈合。实验和临床证据表明，使用这些因子对伤口愈合过程具有治疗优势。据报道，它们对烧伤患者出现的4种伤口有积极作用：浅度烧伤创面、深度烧伤创面、网状皮肤移植间隙和皮肤移植供区。
使用MEDLINE、Ovid和科学网数据库进行全面的文献检索，以确定有关烧伤和伤口愈合中生长因子及其他细胞因子的相关文章。
对细胞因子生长因子及其在烧伤创面愈合中的潜在治疗应用的现有知识进行了讨论和综述。
血小板衍生生长因子、成纤维细胞生长因子、表皮生长因子、转化生长因子α、血管内皮生长因子、胰岛素样生长因子I、神经生长因子、转化生长因子β、粒细胞-巨噬细胞集落刺激因子和羊膜来源的细胞因子溶液均被认为可提高烧伤护理中所遇到的1种或多种此类伤口的愈合速度和质量。
