神经营养因子与发育中啮齿动物大脑中的神经元迁移

Neurotrophins and neuronal migration in the developing rodent brain.

作者信息

Dicou Eleni

机构信息

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1072, USA.

出版信息

Brain Res Rev. 2009 May;60(2):408-17. doi: 10.1016/j.brainresrev.2009.03.001. Epub 2009 Mar 21.

DOI:10.1016/j.brainresrev.2009.03.001

PMID:19306897

Abstract

Neurotrophins are known to be key regulators of neuronal survival, differentiation, function and plasticity in the developing and adult rodent brain. A novel role for neurotrophins has been emerging from recent research, that of motogenic and chemoattractant factors for several populations of migrating neuronal precursors in the developing mouse brain. The aim of the present article is to summarize and discuss the studies that have contributed to the existing body of evidence.

摘要

已知神经营养因子是发育中和成年啮齿动物大脑中神经元存活、分化、功能和可塑性的关键调节因子。近期研究揭示了神经营养因子的一个新作用，即在发育中的小鼠大脑中，它是几种迁移神经元前体细胞群的促运动和趋化因子。本文旨在总结和讨论为现有证据体系做出贡献的研究。