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本文引用的文献

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Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials.锥虫硫醇S-转移酶和锥虫硫氧还蛋白过氧化物酶在抗锑性中的作用。
Antimicrob Agents Chemother. 2008 Apr;52(4):1359-65. doi: 10.1128/AAC.01563-07. Epub 2008 Feb 4.
2
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.ABC转运蛋白MRPA、γ-谷氨酰半胱氨酸合成酶和鸟氨酸脱羧酶在杜氏利什曼原虫天然抗锑分离株中的作用
J Antimicrob Chemother. 2007 Feb;59(2):204-11. doi: 10.1093/jac/dkl494. Epub 2007 Jan 9.
3
Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites.利什曼原虫ABC蛋白基因表达在不同生活阶段及耐药寄生虫中的调控
Eukaryot Cell. 2006 Oct;5(10):1713-25. doi: 10.1128/EC.00152-06.
4
Intracellular location of the ABC transporter PRP1 related to pentamidine resistance in Leishmania major.与硕大利什曼原虫中喷他脒抗性相关的ABC转运蛋白PRP1的细胞内定位
Mol Biochem Parasitol. 2006 Dec;150(2):378-83. doi: 10.1016/j.molbiopara.2006.08.013. Epub 2006 Sep 20.
5
Resistance to antimony and treatment failure in human Leishmania (Viannia) infection.人类利什曼原虫（维扬尼利什曼原虫）感染中的锑耐药性与治疗失败
J Infect Dis. 2006 May 15;193(10):1375-83. doi: 10.1086/503371. Epub 2006 Apr 7.
6
Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites.由于耐药性热带利什曼原虫寄生虫，伊朗皮肤利什曼病对葡糖胺锑治疗无反应。
PLoS Med. 2006 May;3(5):e162. doi: 10.1371/journal.pmed.0030162. Epub 2006 Apr 18.
7
Insight in eukaryotic ABC transporter function by mutation analysis.通过突变分析洞察真核生物ABC转运蛋白的功能。
FEBS Lett. 2006 Feb 13;580(4):1064-84. doi: 10.1016/j.febslet.2006.01.024. Epub 2006 Jan 19.
8
Advances in leishmaniasis.利什曼病的研究进展
Lancet. 2005;366(9496):1561-77. doi: 10.1016/S0140-6736(05)67629-5.
9
Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.ABC转运蛋白MRPA（PGPA）在婴儿利什曼原虫无细胞和细胞内无鞭毛体抗锑性中的作用
Antimicrob Agents Chemother. 2005 May;49(5):1988-93. doi: 10.1128/AAC.49.5.1988-1993.2005.
10
Leishmaniasis: drugs in the clinic, resistance and new developments.利什曼病：临床用药、耐药性及新进展
Drug Resist Updat. 2004 Aug-Oct;7(4-5):257-66. doi: 10.1016/j.drup.2004.07.002.

利什曼原虫ABCC蛋白的细胞内定位及其在抗锑性中的作用。

Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials.

作者信息

Leprohon Philippe, Légaré Danielle, Ouellette Marc

机构信息

Centre de Recherche en Infectiologie, Université Laval, Québec, Canada G1V 4G2.

出版信息

Antimicrob Agents Chemother. 2009 Jun;53(6):2646-9. doi: 10.1128/AAC.01474-08. Epub 2009 Mar 23.

DOI:10.1128/AAC.01474-08
PMID:19307364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2687239/
Abstract

The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.

摘要

利什曼原虫中的ABCC蛋白亚家族由九个成员组成。我们报告称，所有这些蛋白都定位于细胞内，并且至少四个成员ABCC3、ABCC4、ABCC5和ABCC7的过表达能够赋予对锑剂（治疗利什曼原虫的一线药物）的抗性。