Zarember Kol A, Cruz Anna R, Huang Chiung-Yu, Gallin John I
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1456, USA.
Antimicrob Agents Chemother. 2009 Jun;53(6):2654-6. doi: 10.1128/AAC.01547-08. Epub 2009 Mar 23.
Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.
测试了铁螯合剂（乳铁蛋白、去铁胺、去铁酮和环吡酮）单独及与抗真菌药物联合对烟曲霉B5233分生孢子的抗真菌作用。乳铁蛋白、环吡酮和去铁酮抑制真菌生长，而去铁胺则促进真菌生长。酮康唑与环吡酮或去铁酮联合、乳铁蛋白与两性霉素B联合以及氟康唑与去铁酮联合，对分生孢子具有抗真菌协同作用。单独使用铁螯合剂或与抗真菌药物联合使用可能对预防和治疗真菌病有用。
