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针对模拟白色念珠菌心内膜赘生物的抗真菌联合用药

Antifungal combinations against simulated Candida albicans endocardial vegetations.

作者信息

Pai Manjunath P

机构信息

College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA.

出版信息

Antimicrob Agents Chemother. 2009 Jun;53(6):2629-31. doi: 10.1128/AAC.01026-08. Epub 2009 Mar 23.

DOI:10.1128/AAC.01026-08
PMID:19307372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2687236/
Abstract

The in vitro effects of flucytosine (5FC), liposomal amphotericin B (L-AmB), and micafungin (Mica) combinations against two Candida albicans strains that simulated 24-hour-old endocardial vegetations were studied. Mica was superior to 5FC or L-AmB, and the 5FC-L-AmB-Mica combination was superior to all other treatments for one strain but no different from the dual combination of L-AmB-Mica for the other strain.

摘要

研究了氟胞嘧啶（5FC）、脂质体两性霉素B（L-AmB）和米卡芬净（Mica）联合用药对两种模拟24小时龄心内膜赘生物的白色念珠菌菌株的体外作用。米卡芬净优于5FC或L-AmB，5FC-L-AmB-Mica联合用药对一种菌株的效果优于所有其他治疗，但对另一种菌株与L-AmB-Mica联合用药无差异。

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