Métrich Mélanie, Morel Eric, Berthouze Magali, Pereira Laetitia, Charron Philippe, Gomez Ana-Maria, Lezoualc'h Frank
Inserm, U769, Signalisation et Physiopathologie Cardiaque, Châtenay-Malabry, France.
Pharmacol Rep. 2009 Jan-Feb;61(1):146-53. doi: 10.1016/s1734-1140(09)70017-9.
The cyclic AMP (cAMP)-binding proteins, Epac, are guanine nucleotide exchange factors for the Ras-like small GTPases. Since their discovery in 1998 and with the development of specific Epac agonists, many data in the literature have illustrated their critical role in multiple cellular events mediated by the second messenger cAMP. Given the importance of cAMP in cardiovascular physiology and physiopathology, there is a growing interest to delineate the role of these multi-domain Epac in the cardiovascular system. This review will focus on recent pharmacological and biochemical studies aiming at understanding the role of Epac in cardiomyocyte signaling and hypertrophy.
环磷酸腺苷（cAMP）结合蛋白Epac是类Ras小GTP酶的鸟嘌呤核苷酸交换因子。自1998年被发现以来，随着特异性Epac激动剂的开发，文献中的许多数据都表明它们在由第二信使cAMP介导的多种细胞事件中起着关键作用。鉴于cAMP在心血管生理学和病理生理学中的重要性，人们越来越有兴趣阐明这些多结构域Epac在心血管系统中的作用。本综述将聚焦于近期旨在了解Epac在心肌细胞信号传导和肥大中作用的药理学和生物化学研究。
