Capitanio J P, Lerche N W
Department of Psychology, University of California, Davis 95616-8686.
AIDS. 1991 Sep;5(9):1103-6. doi: 10.1097/00002030-199109000-00007.
Infection of macaques by the simian immunodeficiency virus (SIV), like HIV infection in humans, results in a variable time course to clinical disease. Developmental studies of macaques have shown that psychosocial disruption, including social separations, can result in both immediate and long-term immunological consequences. Using colony records on a subset of rhesus macaques (Macaca mulatta) inoculated with SIV at the California Primate Research Center, Davis, California, USA, we constructed regression equations to determine whether the animals' psychosocial histories could explain any of the variability observed in measures of disease progression. After controlling for dosage, age at inoculation, sex, and previous inoculation history, psychosocial variables were found to be significantly associated with several indicators of disease, including latencies to display leukopenia and lymphopenia, weight loss, and survival. We believe these preliminary results suggest an important role for psychosocial processes in affecting disease progression in SIV infection in macaques.
猕猴感染猿猴免疫缺陷病毒（SIV），如同人类感染HIV一样，会导致临床疾病的病程长短不一。对猕猴的发育研究表明，包括社交隔离在内的心理社会干扰会产生即时和长期的免疫后果。利用美国加利福尼亚州戴维斯市加利福尼亚灵长类动物研究中心对一部分接种SIV的恒河猴（猕猴属）的群体记录，我们构建了回归方程，以确定动物的心理社会历史是否能够解释在疾病进展测量中观察到的任何变异性。在控制了剂量、接种时的年龄、性别和先前的接种史之后，发现心理社会变量与疾病的几个指标显著相关，包括出现白细胞减少症和淋巴细胞减少症的潜伏期、体重减轻和存活情况。我们认为这些初步结果表明心理社会过程在影响猕猴SIV感染的疾病进展中起着重要作用。
