Graham Jennifer E, Christian Lisa M, Kiecolt-Glaser Janice K
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
J Behav Med. 2006 Aug;29(4):389-400. doi: 10.1007/s10865-006-9057-4. Epub 2006 May 19.
Both aging processes and psychological stress affect the immune system: Each can dysregulate immune function with a potentially substantial impact on physical health. Worse, the effects of stress and age are interactive. Psychological stress can both mimic and exacerbate the effects of aging, with older adults often showing greater immunological impairment to stress than younger adults. In addition, stressful experiences very early in life can alter the responsiveness of the nervous system and immune system. We review the unique impact of aging and stress on immune function, followed by evidence of interactions between age and stress. Further, we suggest that prenatal or early life stress may increase the likelihood of maladaptive immune responses to stress in late life. An understanding of the interactive effects of stress and age is critical to efforts to determine underlying mechanisms, clarify the directionality of effects, and develop effective interventions in early and late life.
两者都可能使免疫功能失调，对身体健康产生潜在的重大影响。更糟糕的是，压力和年龄的影响是相互作用的。心理压力既能模拟又能加剧衰老的影响，老年人通常比年轻人在压力下表现出更大的免疫损伤。此外，生命早期的应激经历会改变神经系统和免疫系统的反应能力。我们回顾了衰老和压力对免疫功能的独特影响，随后是年龄与压力之间相互作用的证据。此外，我们认为产前或生命早期的压力可能会增加晚年对应激产生适应不良免疫反应的可能性。了解压力和年龄的交互作用对于确定潜在机制、阐明影响的方向性以及制定生命早期和晚期的有效干预措施至关重要。
