Graumann Peter L, Knust Tobias
Microbiology, Faculty for Biology, University of Freiburg, Schänzle Strasse 1, 79104 Freiburg, Germany.
Chromosome Res. 2009;17(2):265-75. doi: 10.1007/s10577-008-9014-x.
Bacteria and archaea possess several different SMC-like proteins, which perform essential functions in a variety of chromosome dynamics, such as chromosome compaction, segregation, and DNA repair. SMC-like proteins localize to distinct sites within the cells at different time points in the cell cycle, or are recruited to sites of DNA breaks and damage. The bacterial SMC (MukB) complex appears to perform a condensin-like function, while SbcC and RecN act early during DNA repair, but apparently at different sites within the cells. Thus, bacterial SMC-like proteins have dynamic functions in chromosome segregation and maintenance of genetic stability.
细菌和古细菌拥有几种不同的类SMC蛋白，它们在多种染色体动态过程中发挥着重要作用，如染色体压缩、分离和DNA修复。类SMC蛋白在细胞周期的不同时间点定位于细胞内的不同位点，或者被招募到DNA断裂和损伤位点。细菌的SMC（MukB）复合物似乎发挥着类似凝缩蛋白的功能，而SbcC和RecN在DNA修复早期发挥作用，但显然是在细胞内的不同位点。因此，细菌类SMC蛋白在染色体分离和遗传稳定性维持中具有动态功能。
