褪黑素对大鼠下丘脑钙摄取双峰效应的时间依赖性。简短通讯。
Time-dependency for the bimodal effect of melatonin on calcium uptake in rat hypothalamus. Short communication.
作者信息
Rosenstein R E, Golombek D A, Kanterewicz B I, Cardinali D P
机构信息
Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
出版信息
J Neural Transm Gen Sect. 1991;85(3):243-7. doi: 10.1007/BF01244949.
The activity of 0.01-1 microM of melatonin on depolarization-induced 45Ca2+ influx by hypothalamic synaptosomes of rats killed at late evening (2000 h) depended on melatonin preincubation time, exhibiting an early (10 min) stimulation of uptake and an inhibition after 30 min of incubation. Both stimulatory and inhibitory effects were maximal at 2000 h and tended to a minimum at 2400 h, exhibiting intermediate values at 400 h. At 1000 h, only inhibitory effects of melatonin (1 microM) on Ca2+ uptake were found.
褪黑素浓度为0.01 - 1微摩尔时，对傍晚（20:00）处死的大鼠下丘脑突触体去极化诱导的45Ca2+内流的影响，取决于褪黑素预孵育时间，表现为孵育10分钟时摄取早期刺激，孵育30分钟后抑制。刺激和抑制作用在20:00时均最大，在24:00时趋于最小，在4:00时呈现中间值。在10:00时，仅发现褪黑素（1微摩尔）对Ca2+摄取有抑制作用。
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