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松果体切除、颈上神经节切除或给大鼠注射褪黑素后下丘脑神经递质摄取的变化。

Changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats.

作者信息

Cardinali D P

出版信息

Neuroendocrinology. 1975;19(1):91-5. doi: 10.1159/000122429.

DOI:10.1159/000122429
PMID:1692
Abstract

Rats subjected to pinealectomy or to pinealectomy plus bilateral superior cervical ganglionectomy exhibited depressed serotonin uptake by hypothalamic synaptosomes; norepinephrine, dopamine or glutamate uptake was not affected by any of the surgical procedures. Treatment with melatonin resulted in inhibition of hypothalamic serotonin accumulation but it did not modify the uptake of norepinephrine, dopamine or glutamate. These data suggest a relationship between the pineal gland and the serotoninergic nerve endings of the hypothalamus.

摘要

接受松果体切除或松果体切除加双侧颈上神经节切除的大鼠，其下丘脑突触体对血清素的摄取受到抑制；去甲肾上腺素、多巴胺或谷氨酸的摄取不受任何手术操作的影响。褪黑素治疗导致下丘脑血清素积累受到抑制，但它并未改变去甲肾上腺素、多巴胺或谷氨酸的摄取。这些数据表明松果体与下丘脑的血清素能神经末梢之间存在关联。

相似文献

1
Changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats.松果体切除、颈上神经节切除或给大鼠注射褪黑素后下丘脑神经递质摄取的变化。
Neuroendocrinology. 1975;19(1):91-5. doi: 10.1159/000122429.
2
Effects of melatonin on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus.褪黑素对大鼠下丘脑富含突触体的匀浆中神经递质摄取和释放的影响。
Neuroendocrinology. 1975;18(1):72-85. doi: 10.1159/000122385.
3
Effects of pinealectomy and melatonin treatments on serotonin uptake and release from synaptosomes of rat hypothalamic regions.松果体切除和褪黑素处理对大鼠下丘脑区域突触体中5-羟色胺摄取和释放的影响。
Neurochem Res. 1995 Oct;20(10):1127-32. doi: 10.1007/BF00995374.
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Diurnal rhythms in ornithine decarboxylase activity and norepinephrine and acetylcholine synthesis and acetylcholine synthesis of rat submaxillary lymph nodes: effect of pinealectomy, superior cervical ganglionectomy and melatonin replacement.大鼠下颌下淋巴结中鸟氨酸脱羧酶活性、去甲肾上腺素和乙酰胆碱合成的昼夜节律：松果体切除、颈上神经节切除及褪黑素替代的影响
Neuroimmunomodulation. 1996 Mar-Jun;3(2-3):102-11. doi: 10.1159/000097234.
5
Changes in serotonin level and turnover in discrete hypothalamic nuclei after pinealectomy and melatonin administration to rats.松果体切除及给大鼠注射褪黑素后，下丘脑不同核团中血清素水平及代谢的变化。
Neurochem Int. 1996 Dec;29(6):651-8. doi: 10.1016/s0197-0186(96)00028-9.
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Effect of pinealectomy, superior cervical ganglionectomy, or melatonin treatment on 24-hour rhythms in ornithine decarboxylase and tyrosine hydroxylase activities of rat spleen.松果体切除、颈上神经节切除或褪黑素处理对大鼠脾脏鸟氨酸脱羧酶和酪氨酸羟化酶活性24小时节律的影响。
J Pineal Res. 1997 May;22(4):210-20. doi: 10.1111/j.1600-079x.1997.tb00324.x.
7
[Comparative evaluation of the effect of serotonin, melatonin and methoxytryptamine on the content of biogenic amines in the hypothalamus and gonadotropic hormones in the pituitary gland depending on the periodicity of phases of the estrous cycle in rats].[根据大鼠发情周期各阶段的周期性，比较血清素、褪黑素和甲氧基色胺对下丘脑生物胺含量及垂体促性腺激素的影响]
Probl Endokrinol (Mosk). 1977 Sep-Oct;23(5):56-8.
8
Effects of hypophysectomy, adrenalectomy and corticosterone treatment on uptake and release of putative central neurotransmitters by rat hypothalamic tissue in vitro.垂体切除术、肾上腺切除术及皮质酮处理对大鼠下丘脑组织体外摄取和释放假定中枢神经递质的影响。
Life Sci. 1976 Dec 1;19(11):1719-25. doi: 10.1016/0024-3205(76)90079-5.
9
The nyctohemeral rhythm of plasma prolactin: effects of ganglionectomy, pinealectomy, constant light, constant darkness or 6-OH-dopamine administration.血浆催乳素的昼夜节律：神经节切除术、松果体切除术、持续光照、持续黑暗或给予6-羟基多巴胺的影响。
Endocrinology. 1975 May;96(5):1230-40. doi: 10.1210/endo-96-5-1230.
10
Dose-related effects of cysteamine treatment on hypothalamic and striatal dopamine, noradrenaline and serotonin neurotransmission.半胱胺治疗对下丘脑和纹状体多巴胺、去甲肾上腺素及5-羟色胺神经传递的剂量相关效应。
Acta Physiol Hung. 1985;66(2):213-7.

引用本文的文献

1
Effects of pinealectomy and melatonin treatments on serotonin uptake and release from synaptosomes of rat hypothalamic regions.松果体切除和褪黑素处理对大鼠下丘脑区域突触体中5-羟色胺摄取和释放的影响。
Neurochem Res. 1995 Oct;20(10):1127-32. doi: 10.1007/BF00995374.
2
The sympathetic superior cervical ganglia as peripheral neuroendocrine centers.作为外周神经内分泌中心的交感神经颈上神经节。
J Neural Transm. 1981;52(1-2):1-21. doi: 10.1007/BF01253092.
3
Enhancement of melatonin's antigonadal action by daily injections of the serotonin uptake inhibitor fluoxetine in male hamsters.
通过每日给雄性仓鼠注射血清素摄取抑制剂氟西汀来增强褪黑素的抗性腺作用。
J Neural Transm. 1985;64(2):151-61. doi: 10.1007/BF01245976.
4
Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system.褪黑素对光诱导持续性发情-无排卵综合征中排卵诱导的影响及脑5-羟色胺能系统的可能作用。
J Endocrinol Invest. 1978 Oct;1(4):305-10. doi: 10.1007/BF03350974.
5
Neuroendocrine function in long-term pinealectomized male rats, following visual and audiogenic stress.长期松果体切除的雄性大鼠在视觉和听觉应激后的神经内分泌功能。
J Neural Transm. 1979;46(2):113-22. doi: 10.1007/BF01250333.