培南类抗生素FCE 22101和FCE 25199与庆大霉素联合应用对败血症分离菌的协同及累积杀菌作用。

Synergy and cumulated killing effect of the penems FCE 22101 and FCE 25199 in combination with gentamicin against bacteria isolated from septicaemia.

作者信息

Bergholm A M, Dornbusch K

机构信息

Department of Clinical Microbiology, Umeå University, Sweden.

出版信息

APMIS. 1991 Oct;99(10):916-24. doi: 10.1111/j.1699-0463.1991.tb01279.x.

DOI:10.1111/j.1699-0463.1991.tb01279.x

PMID:1930964

Abstract

Blood isolates of Enterococcus faecalis, Streptococcus sanguis, Staphylococcus aureus, E. coli and Klebsiella oxytoca were tested for their synergistic and cumulated killing effect (CKE) with the new penems FCE 22101 or FCE 25199 in combination with gentamicin. The tissue cage model in rabbits was used to study the CKE in vivo after antibiotic treatment of the bacteria in vitro. Synergy was observed within two to seven h with all isolates in early logarithmic phase, except with S. aureus, which was rapidly killed by the penems alone. After one h treatment with the antibiotic combinations in vitro, a CKE was demonstrated for up to six h both in vitro and in vivo. The magnitude of the CKE differed between strains and in vitro vs. in vivo.

摘要

对粪肠球菌、血链球菌、金黄色葡萄球菌、大肠杆菌和产酸克雷伯菌的血液分离株，测试了新型青霉烯类药物FCE 22101或FCE 25199与庆大霉素联合使用时的协同和累积杀菌作用（CKE）。采用兔组织笼模型研究体外抗生素处理细菌后体内的CKE。除金黄色葡萄球菌外，在对数生长期早期的所有分离株中，两到七小时内观察到协同作用，金黄色葡萄球菌单独被青霉烯类药物迅速杀灭。体外经抗生素组合处理一小时后，体外和体内均显示长达六小时的CKE。CKE的强度在不同菌株之间以及体外和体内有所不同。