Bach V T, Webb D W, Thadepalli H
Chemotherapy. 1980;26(1):21-7. doi: 10.1159/000237879.
The potential synergistic effect of piperacillin with gentamicin was examined against five isolates each of Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis isolated from patients with endocarditis. Piperacillin and gentamicin synergistically inhibited all strains of P. aeruginosa and S. aureus tested. They exerted no synergistic effect against S. faecalis. Piperacillin and gentamicin synergism may be clinically tested in the treatment of serious pseudomonas and staphylococcal infections but not against infections caused by S. faecalis.
针对从心内膜炎患者中分离出的铜绿假单胞菌、金黄色葡萄球菌和粪肠球菌各5株菌株，研究了哌拉西林与庆大霉素的潜在协同作用。哌拉西林和庆大霉素协同抑制了所有受试的铜绿假单胞菌和金黄色葡萄球菌菌株。它们对粪肠球菌没有协同作用。哌拉西林和庆大霉素的协同作用可在治疗严重的假单胞菌和葡萄球菌感染中进行临床测试，但不适用于治疗由粪肠球菌引起的感染。
