单剂量口服多拉菌素、依普菌素和塞拉菌素对大鼠自然感染鼠管状线虫的急性影响。

The acute effects of single-dose orally administered doramectin, eprinomectin and selamectin on natural infections of Syphacia muris in rats.

作者信息

Sevimli Feride Kircali, Kozan Esma, Sevimli Alper, Doğan Nurhan, Bülbül Aziz

机构信息

Department of Parasitology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.

出版信息

Exp Parasitol. 2009 Jul;122(3):177-81. doi: 10.1016/j.exppara.2009.03.008. Epub 2009 Mar 24.

DOI:10.1016/j.exppara.2009.03.008

PMID:19318096

Abstract

This study was designed to determine the acute effects of a single-dose of orally administered doramectin, eprinomectin and selamectin on Syphacia muris infection in rats. Rats, naturally infected with S. muris, were divided into four groups: three different treatment groups (n=7) and one positive control (n=7). Cellophane tape preparations were obtained from the treated rats on day 0 pre-treatment and on days 2, 4 and 6 post-treatment. Syphacia sp. eggs were counted. Eprinomectin was found to be 100% effective in eliminating eggs on two post-treatment. However when egg counts on day 6 post-treatment were compared with pre-treatment egg counts, doramectin and selamectin were found to be 99.32 and 98.77% effective in eliminating eggs, respectively. On day 7 post-treatment, blood samples were obtained from all groups, and then the rats were necropsied. Doramectin, eprinomectin and selamectin were found to be 100% effective in eliminating adult S. muris, when compared with the positive control group.

摘要

本研究旨在确定单剂量口服多拉菌素、依普菌素和塞拉菌素对大鼠感染鼠管状线虫的急性影响。自然感染鼠管状线虫的大鼠被分为四组：三个不同的治疗组（每组n = 7）和一个阳性对照组（n = 7）。在治疗前第0天以及治疗后第2、4和6天从治疗后的大鼠获取透明胶带标本，对鼠管状线虫属虫卵进行计数。结果发现，依普菌素在治疗后两天对虫卵的清除率达100%。然而，将治疗后第6天的虫卵计数与治疗前的虫卵计数进行比较时，发现多拉菌素和塞拉菌素对虫卵的清除率分别为99.32%和98.77%。在治疗后第7天，从所有组采集血样，然后对大鼠进行剖检。与阳性对照组相比，发现多拉菌素、依普菌素和塞拉菌素对成年鼠管状线虫的清除率达100%。