De Amici M, Marseglia G, Quaglini S, Moratti R, Alesina R, Torre C, Ciprandi G
Clinica Pediatrica, Fondazione IRCCS San Matteo University of Pavia, Italy.
J Biol Regul Homeost Agents. 2009 Jan-Mar;23(1):37-44.
The IgG response to allergens is well-known, however few studies have investigated IgG and IgG4 production in normal subjects. Therefore, total IgG and IgG4 serum levels specific for 6 common inhalant allergens were measured in 282 non-allergic subjects to establish reference values at different ages and sex. Thus, 282 subjects were studied (141 female and 141 male) ranging from pre-school to adult age, all living in Northern Italy at the time of the study. Family history of first degree relatives and personal history were negative for allergic diseases. The findings obtained in this study indicate that: i) reference values for specific IgG4 and IgG levels against the allergen studied should take into account both the sex and age of the subject evaluated; ii) there is a difference in trend for age between seasonal and perennial allergens and iii) the relationships between age and specific IgG4 and IgG levels have different slopes. In conclusion, relevant differences exist in the distribution of IgG and IgG4 levels in normal subjects.
对过敏原的IgG反应是众所周知的，然而很少有研究调查正常受试者中IgG和IgG4的产生情况。因此，对282名非过敏受试者测量了针对6种常见吸入性过敏原的总IgG和IgG4血清水平，以建立不同年龄和性别的参考值。本研究共纳入282名受试者（141名女性和141名男性），年龄范围从学龄前到成年，研究期间均居住在意大利北部。一级亲属的家族史和个人史均无过敏性疾病。本研究的结果表明：i）针对所研究过敏原的特异性IgG4和IgG水平的参考值应考虑所评估受试者的性别和年龄；ii）季节性和常年性过敏原的年龄趋势存在差异；iii）年龄与特异性IgG4和IgG水平之间的关系具有不同的斜率。总之，正常受试者中IgG和IgG4水平的分布存在显著差异。
