贫铀诱发白血病过程中的DNA甲基化
DNA methylation during depleted uranium-induced leukemia.
作者信息
Miller Alexandra C, Stewart Michael, Rivas Rafael
机构信息
Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, MD 20889-5603, USA.
出版信息
Biochimie. 2009 Oct;91(10):1328-30. doi: 10.1016/j.biochi.2009.03.010. Epub 2009 Mar 24.
OBJECTIVES
The radioactive heavy metal depleted uranium (DU) is used in kinetic-energy penetrators in military applications. The objective of this study was to determine involvement of DNA methylation in DU-induced leukemia.
METHODS
Methylation was measured by direct analysis of 5-methylcytosine content of spleen DNA in DU leukemic mice.
RESULTS
Spleen hypomethylation occurred during DU-induced leukemogenesis (chronic internal DU exposure). Aberrant gene transcription was also detected.
CONCLUSIONS
Epigenetic mechanisms are implicated in DU-induced leukemia. These data are evidence of aberrant DNA hypomethylation being associated with DU leukemogenesis.
目的
放射性重金属贫铀（DU）用于军事应用中的动能穿甲弹。本研究的目的是确定DNA甲基化在DU诱导的白血病中的作用。
方法
通过直接分析DU白血病小鼠脾脏DNA的5-甲基胞嘧啶含量来测量甲基化。
结果
在DU诱导的白血病发生过程中（慢性内源性DU暴露）出现脾脏低甲基化。还检测到异常基因转录。
结论
表观遗传机制与DU诱导的白血病有关。这些数据证明异常DNA低甲基化与DU白血病发生相关。
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