Tomizawa Yutaka, Wang Kenneth K
Barrett's Esophagus Unit, Alfred Main, Gastroenterology Diagnostic Unit, St. Mary's Hospital, 200 2nd Street SW, Rochester, MN 55905, USA.
Gastroenterol Clin North Am. 2009 Mar;38(1):59-73, viii. doi: 10.1016/j.gtc.2009.01.014.
The incidence of esophageal cancer, especially esophageal adenocarcinoma, is increasing and its high mortality rate is a notable fact. Improving survival rates of this disease depend on earlier detection through screening and surveillance; however, standard diagnostic modalities, such as endoscopy with biopsy, have several limitations as screening tools, including low negative predictive value and relatively high cost. Recently developed biomarkers such as FISH and improved imaging techniques, may help overcome current problems and provide improved screening and surveillance for esophageal cancer.
食管癌,尤其是食管腺癌的发病率正在上升,其高死亡率是一个显著事实。提高这种疾病的生存率取决于通过筛查和监测进行早期检测;然而,标准的诊断方法,如内镜活检,作为筛查工具存在一些局限性,包括低阴性预测值和相对较高的成本。最近开发的生物标志物如荧光原位杂交(FISH)和改进的成像技术,可能有助于克服当前的问题,并为食管癌提供更好的筛查和监测。