弱视眼的视网膜神经纤维层厚度
Retinal nerve fiber layer thickness in amblyopic eyes.
作者信息
Repka Michael X, Kraker Raymond T, Tamkins Susanna M, Suh Donny W, Sala Nicholas A, Beck Roy W
机构信息
Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, USA.
出版信息
Am J Ophthalmol. 2009 Jul;148(1):143-7. doi: 10.1016/j.ajo.2009.01.015. Epub 2009 Mar 27.
PURPOSE
To compare the peripapillary retinal nerve fiber layer (RNFL) thickness of amblyopic and fellow eyes. We hypothesized that the RNFL of the amblyopic eye may be thinner.
DESIGN
Prospective, cross-sectional, observational case series.
METHODS
Optical coherence tomography of the peripapillary RNFL thickness of amblyopic and fellow eyes was performed in 37 patients 7 to 12 years of age (mean age +/- standard deviation, 9.2 +/- 1.5 years) with unilateral strabismic, anisometropic, or combined-mechanism amblyopia enrolled in a randomized treatment trial.
RESULTS
Mean global RNFL thickness of the amblyopic and fellow eyes was 111.4 and 109.6 microm, respectively (mean difference, 1.8 microm thicker in the amblyopic eyes; 95% confidence interval, -0.6 to 4.3 microm). The amblyopic eye was 8 microm or more thicker than the fellow eye in 9 patients (24%); the fellow eye was 8 microm or more thicker than the amblyopic eye in 2 patients (5%); and the difference was within test-retest variability (7 microm) in 26 patients (70%).
CONCLUSIONS
Our findings do not indicate that peripapillary RNFL thickness is thinner in eyes with moderate amblyopia compared with their fellow eyes.
目的
比较弱视眼和对侧眼的视乳头周围视网膜神经纤维层（RNFL）厚度。我们假设弱视眼的RNFL可能较薄。
设计
前瞻性、横断面观察性病例系列研究。
方法
对37例年龄在7至12岁（平均年龄±标准差，9.2±1.5岁）的单侧斜视性、屈光参差性或混合机制性弱视患者进行随机治疗试验，对其弱视眼和对侧眼的视乳头周围RNFL厚度进行光学相干断层扫描。
结果
弱视眼和对侧眼的平均整体RNFL厚度分别为111.4微米和109.6微米（平均差异，弱视眼厚1.8微米；95%置信区间，-0.6至4.3微米）。9例患者（24%）的弱视眼比对侧眼厚8微米或更多；2例患者（5%）的对侧眼比弱视眼厚8微米或更多；26例患者（70%）的差异在重测变异性（7微米）范围内。
结论
我们的研究结果并不表明中度弱视眼的视乳头周围RNFL厚度比对侧眼薄。
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