Kantarci Feride Aylin, Tatar Mehmet Gurkan, Uslu Hasim, Colak Hatice Nur, Yildirim Aydin, Goker Hasan, Gurler Bulent
Department of Ophthalmology, School of Medicine, Fatih University, Istanbul - Turkey.
Eur J Ophthalmol. 2015 Sep-Oct;25(5):437-42. doi: 10.5301/ejo.5000594. Epub 2015 Mar 21.
To evaluate choroidal thickness, macular thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness in amblyopic eyes compared to fellow and normal control eyes using high-definition spectral-domain optical coherence tomography (SD-OCT).
Fifty-four without any systemic problem and ocular disease participated in this prospective study. Inclusion criteria included individuals older than 18 years with anisometropic amblyopia. Choroidal thickness, central macular thickness (CMT), and RNFL thickness were measured by using enhanced depth imaging SD-OCT. The choroidal thickness was measured at the fovea and at 500 µm intervals from the foveal center in both temporal and nasal directions. Axial length measurements of the cases were also recorded.
Mean peripapillary RNFL thickness of the amblyopic, fellow, and control eyes was 107.5 ± 15.5 µm, 109.3 ± 12.7 µm, and 108.8 ± 8.6 µm, respectively (p = 0.343). The average CMT was 231.7 ± 14.7 µm in amblyopic eyes, 232.5 ± 15.7 μm in fellow eyes, and 230.8 ± 14.8 µm in control eyes (p = 0.599). Mean subfoveal choroidal thickness was significantly greater in the amblyopic eyes than in the fellow and control eyes (396.3 ± 104.3 µm, 361.0 ± 103.9 µm, 390.6 ± 91.7 µm). Mean axial measurement in amblyopic eyes was 22.7 ± 1.3 mm (20.5-26.1), in fellow eyes 23.1 ± 0.9 mm (20.9-25.0), and in control eyes 23.3 ± 0.9 mm.
In adults with anisometropic amblyopia, subfoveal, temporal, and nasal choroidal thickness of amblyopic eyes are significantly thicker than in fellow eyes. However, no significant differences in peripapillary RNFL thickness or CMT were found between amblyopic and fellow or control eyes.
使用高分辨率光谱域光学相干断层扫描（SD - OCT）评估弱视眼与对侧眼及正常对照眼相比的脉络膜厚度、黄斑厚度和视乳头周围视网膜神经纤维层（RNFL）厚度。
54名无任何全身问题和眼部疾病的受试者参与了这项前瞻性研究。纳入标准包括年龄大于18岁的屈光参差性弱视个体。使用增强深度成像SD - OCT测量脉络膜厚度、中心黄斑厚度（CMT）和RNFL厚度。在黄斑中心凹以及从黄斑中心向颞侧和鼻侧每隔500 µm处测量脉络膜厚度。还记录了病例的眼轴长度测量值。
弱视眼、对侧眼和对照眼的平均视乳头周围RNFL厚度分别为107.5±15.5 µm、109.3±12.7 µm和108.8±8.6 µm（p = 0.343）。弱视眼的平均CMT为231.7±14.7 µm，对侧眼为232.5±15.7 µm，对照眼为230.8±14.8 µm（p = 0.599）。弱视眼的黄斑中心凹下脉络膜平均厚度显著大于对侧眼和对照眼（396.3±104.3 µm，361.0±103.9 µm，390.6±91.7 µm）。弱视眼的平均眼轴测量值为22.7±1.3 mm（20.5 - 26.1），对侧眼为23.1±0.9 mm（20.9 - 25.0），对照眼为23.3±0.9 mm。
在屈光参差性弱视成人中，弱视眼的黄斑中心凹下、颞侧和鼻侧脉络膜厚度明显厚于对侧眼。然而，弱视眼与对侧眼或对照眼之间在视乳头周围RNFL厚度或CMT方面未发现显著差异。
