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一种新型共聚物，以羟丙基-α-环糊精与低分子量聚乙烯亚胺偶联为基础，作为体外基因传递载体。

A novel co-polymer based on hydroxypropyl alpha-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector.

机构信息

School of Life Science, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, P. R. China.

Institute of Immunology, Zhejiang University, Yuhangtang Road 388, Hangzhou, P. R. China.

出版信息

Int J Mol Sci. 2008 Nov;9(11):2278-2289. doi: 10.3390/ijms9112278. Epub 2008 Nov 21.

DOI:10.3390/ijms9112278
PMID:19330075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2635622/
Abstract

A novel co-polymer based on 2-hydroxypropyl-alpha-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy.

摘要

一种新型共聚物，以低分子量聚乙烯亚胺交联 2-羟丙基-α-环糊精作为基因传递载体。共聚物可紧密结合和浓缩 DNA。与 SK-BR-3 细胞中的 PEI 25kDa 相比，它的细胞毒性更低。在完全血清培养基中，共聚物在 SK-BR-3 细胞中的转染效率比 PEI 25kDa 高 5.5 倍以上。它是一种有潜力的基因治疗候选载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/83a63b9855b0/ijms-9-2278f9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/4c76a774c483/ijms-9-2278f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/29ed1dfe79ef/ijms-9-2278f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/6dce8feb197e/ijms-9-2278f6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/19485ba59514/ijms-9-2278f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/83a63b9855b0/ijms-9-2278f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/3de298d468ac/ijms-9-2278f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/bba1fd68c440/ijms-9-2278f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/fef5c215c597/ijms-9-2278f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/4c76a774c483/ijms-9-2278f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/29ed1dfe79ef/ijms-9-2278f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/6dce8feb197e/ijms-9-2278f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/a0461544fd23/ijms-9-2278f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/19485ba59514/ijms-9-2278f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38fa/2635622/83a63b9855b0/ijms-9-2278f9.jpg

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