糖皮质激素对人类记忆的 hormetic 影响。 （注：“hormetic”可能是特定专业领域的术语，目前没有完全对应的常见中文表述，这里保留英文以便准确传达原文信息）
Hormetic influence of glucocorticoids on human memory.
作者信息
Lupien Sonia J, Buss Claudia, Schramek Tania E, Maheu Francoise, Pruessner Jens
机构信息
Laboratory of Human Stress Research, Douglas Hospital Research Center, Department of Psychiatry, McGill University, Department of Neurology and Neurosurgery, McGill University, Montreal.
出版信息
Nonlinearity Biol Toxicol Med. 2005 Jan;3(1):23-56. doi: 10.2201/nonlin.003.01.003.
Abstract
In this paper, we discuss the effects of glucocorticoids on human learning and memory using the recent model of hormesis proposed by Calabrese and collaborators. Although acute increases in glucocorticoids have been shown to impair memory function in humans, other studies report no such impairments or, in contrast, beneficial effects of acute glucocorticoid increases on human memory function. We summarize these studies and assess whether the wealth of data obtained in humans with regard to the effects of acute increase of glucocorticoids on human cognition are in line with a hormetic function. We then discuss several factors that will have to be taken into account in order to confirm the presence of a hormetic function between glucocorticoids and human cognitive performance.
摘要
在本文中，我们使用卡拉布雷斯及其合作者最近提出的兴奋效应模型，探讨糖皮质激素对人类学习和记忆的影响。虽然已有研究表明，糖皮质激素的急性增加会损害人类的记忆功能，但其他研究报告称不存在此类损害，或者相反，急性增加糖皮质激素对人类记忆功能有有益影响。我们总结了这些研究，并评估在人类中获得的关于急性增加糖皮质激素对人类认知影响的大量数据是否符合兴奋效应功能。然后，我们讨论了为确认糖皮质激素与人类认知表现之间存在兴奋效应功能而必须考虑的几个因素。
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