Douroudis K, Prans E, Kisand K, Nemvalts V, Uibo R
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila Str 19, Tartu 51014, Estonia.
Clin Chim Acta. 2009 May;403(1-2):226-8. doi: 10.1016/j.cca.2009.03.036. Epub 2009 Mar 28.
Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation involved in the down-regulation of immune response. Polymorphisms within the CTLA-4 gene have been suggested to confer susceptibility to autoimmune endocrine disorders.
In order to evaluate the impact of allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the CT60 A/G SNP and the CTBC217_1 C/T SNP were studied in a population of Estonian origin, including 61 LADA patients and 230 controls.
It was found that the CT60 GG genotype (p=0.004) and the CTBC217_1 TT genotype (p=0.007) were significant associated with LADA.
Our investigation revealed that not only type 1 diabetes but also LADA is associated with CTLA-4 gene polymorphisms. The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations.
细胞毒性T淋巴细胞抗原4（CTLA-4）分子是T细胞活化的重要调节因子，参与免疫反应的下调。CTLA-4基因内的多态性被认为与自身免疫性内分泌疾病易感性有关。
为了评估CTLA-4基因等位基因变异对成人隐匿性自身免疫性糖尿病（LADA）的影响，在爱沙尼亚人群中研究了CT60 A/G单核苷酸多态性（SNP）和CTBC217_1 C/T SNP，该人群包括61例LADA患者和230名对照。
发现CT60 GG基因型（p = 0.004）和CTBC217_1 TT基因型（p = 0.007）与LADA显著相关。
我们的研究表明，不仅1型糖尿病，LADA也与CTLA-4基因多态性有关。CTLA-4基因在LADA发病机制中的作用尚不明确，需要进一步研究。
