细胞毒性T淋巴细胞抗原4基因多态性与成人隐匿性自身免疫性糖尿病相关。
Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults.
作者信息
Douroudis K, Prans E, Kisand K, Nemvalts V, Uibo R
机构信息
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila Str 19, Tartu 51014, Estonia.
出版信息
Clin Chim Acta. 2009 May;403(1-2):226-8. doi: 10.1016/j.cca.2009.03.036. Epub 2009 Mar 28.
BACKGROUND
Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation involved in the down-regulation of immune response. Polymorphisms within the CTLA-4 gene have been suggested to confer susceptibility to autoimmune endocrine disorders.
METHODS
In order to evaluate the impact of allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the CT60 A/G SNP and the CTBC217_1 C/T SNP were studied in a population of Estonian origin, including 61 LADA patients and 230 controls.
RESULTS
It was found that the CT60 GG genotype (p=0.004) and the CTBC217_1 TT genotype (p=0.007) were significant associated with LADA.
CONCLUSIONS
Our investigation revealed that not only type 1 diabetes but also LADA is associated with CTLA-4 gene polymorphisms. The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations.
背景
细胞毒性T淋巴细胞抗原4（CTLA-4）分子是T细胞活化的重要调节因子，参与免疫反应的下调。CTLA-4基因内的多态性被认为与自身免疫性内分泌疾病易感性有关。
方法
为了评估CTLA-4基因等位基因变异对成人隐匿性自身免疫性糖尿病（LADA）的影响，在爱沙尼亚人群中研究了CT60 A/G单核苷酸多态性（SNP）和CTBC217_1 C/T SNP，该人群包括61例LADA患者和230名对照。
结果
发现CT60 GG基因型（p = 0.004）和CTBC217_1 TT基因型（p = 0.007）与LADA显著相关。
结论
我们的研究表明，不仅1型糖尿病，LADA也与CTLA-4基因多态性有关。CTLA-4基因在LADA发病机制中的作用尚不明确，需要进一步研究。
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