控制基因组功能的多蛋白复合物的组装。
Assembly of multiprotein complexes that control genome function.
作者信息
Dinant Christoffel, Luijsterburg Martijn S, Höfer Thomas, von Bornstaedt Gesa, Vermeulen Wim, Houtsmuller Adriaan B, van Driel Roel
机构信息
Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, Netherlands.
出版信息
J Cell Biol. 2009 Apr 6;185(1):21-6. doi: 10.1083/jcb.200811080. Epub 2009 Mar 30.
Abstract
Live-cell imaging studies aided by mathematical modeling have provided unprecedented insight into assembly mechanisms of multiprotein complexes that control genome function. Such studies have unveiled emerging properties of chromatin-associated systems involved in DNA repair and transcription.
摘要
借助数学建模的活细胞成像研究为控制基因组功能的多蛋白复合物的组装机制提供了前所未有的见解。此类研究揭示了参与DNA修复和转录的染色质相关系统的新特性。
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