Stender Mogens T, Frøkjaer Jens B, Larsen Torben B, Lundbye-Christensen Søren, Thorlacius-Ussing Ole
Department of Surgical Gastroenterology A, Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark.
Dis Colon Rectum. 2009 Mar;52(3):446-51. doi: 10.1007/DCR.0b013e318197e2b2.
The study examined if preoperative plasma D-dimer level was associated with the postoperative cumulative incidence of deep venous thrombosis in patients with colorectal cancer admitted for intended curative surgery.
In 176 consecutive patients with newly-diagnosed colorectal cancer and absence of preoperative deep venous thrombosis, we measured the preoperative plasma D-dimer levels and performed compression ultrasonography for deep venous thrombosis prior to surgery, as well as one week, one month, and one year after surgery.
The cumulative incidence of deep venous thrombosis up to one year after surgery was 20 percent (95 percent confidence interval, 12 to 31 percent) in the positive D-dimer group compared with 5 percent (95 percent confidence interval, 2 to 12 percent) in the negative D-dimer group. The adjusted hazard ratio of deep venous thrombosis in the positive vs. the negative D-dimer group was 6.53 (95 percent confidence interval, 1.58 to 27.0).
A positive preoperative D-dimer was associated with a higher cumulated incidence of postoperative deep venous thrombosis. D-dimer might be useful in identifying those colorectal cancer patients who fail to respond to standard prophylaxis for deep venous thrombosis.
本研究旨在探讨拟行根治性手术的结直肠癌患者术前血浆D - 二聚体水平是否与术后深静脉血栓形成的累积发生率相关。
在176例新诊断的、术前无深静脉血栓形成的连续结直肠癌患者中，我们测量了术前血浆D - 二聚体水平，并在手术前以及术后1周、1个月和1年进行了深静脉血栓形成的加压超声检查。
D - 二聚体阳性组术后1年内深静脉血栓形成的累积发生率为20%（95%置信区间，12%至31%），而D - 二聚体阴性组为5%（95%置信区间，2%至12%）。D - 二聚体阳性组与阴性组相比，深静脉血栓形成的校正风险比为6.53（95%置信区间，1.58至27.0）。
术前D - 二聚体阳性与术后深静脉血栓形成的累积发生率较高相关。D - 二聚体可能有助于识别那些对深静脉血栓形成标准预防措施无反应的结直肠癌患者。
