Department of Oncology, Anning First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming, 650300, China.
Department of Oncology, Ziyang Hospital, West China Hospital, Sichuan University, Ziyang, 641300, China.
Biomark Med. 2024;18(8):373-383. doi: 10.1080/17520363.2024.2342239. Epub 2024 Jun 4.
This retrospective clinical study was designed to examine the predictive value of thromboelastography (TEG) combined with coagulation function for venous thromboembolism (VTE) in hospitalized patients with cancer. Among 215 patients admitted between May 2020 and January 2022, 39 (18.14%) were diagnosed with VTE during hospitalization. Significant differences were found in D-dimer, ATIII and TEG parameters (maximum amplitude and coagulation index) between VTE-positive and VTE-negative patients (p < 0.05). Multivariate analysis revealed tumor node metastasis stage, concomitant infection, smoking history and D-dimer as independently associated with VTE. The constructed model and D-dimer areas under the curve were 0.809 and 0.764, respectively. TEG parameters were not significantly predictive indicators for VTE, with D-dimer remaining a key predictor.
本回顾性临床研究旨在探讨血栓弹力图（TEG）联合凝血功能对住院癌症患者静脉血栓栓塞症（VTE）的预测价值。在 2020 年 5 月至 2022 年 1 月期间收治的 215 例患者中，39 例（18.14%）在住院期间被诊断为 VTE。VTE 阳性和 VTE 阴性患者的 D-二聚体、ATIII 和 TEG 参数（最大振幅和凝血指数）存在显著差异（p<0.05）。多因素分析显示，肿瘤淋巴结转移分期、合并感染、吸烟史和 D-二聚体与 VTE 独立相关。构建的模型和 D-二聚体的曲线下面积分别为 0.809 和 0.764。TEG 参数不是 VTE 的显著预测指标，D-二聚体仍然是关键预测指标。
