Visconti Roberta, Grieco Domenico
CEINGE Biotecnologie Avanzate, via Comunale Margherita 482, 80145 Naples, Italy.
Curr Opin Drug Discov Devel. 2009 Mar;12(2):240-5.
Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that counteract tumor development. In this review, recent findings that relate oxidative stress to cancer-associated conditions, such as chronic inflammation, steroid hormone signaling and altered chromosome segregation, are highlighted, and how these studies may identify new targets for the development of drugs and strategies for cancer prevention and cure is discussed.
癌症的起始和进展与氧化应激有关，氧化应激是一种活性氧或氮物种的产生与清除之间的平衡被改变的状态。氧化应激具有多种促肿瘤作用，例如增加DNA突变率或诱导DNA损伤、基因组不稳定和细胞增殖。相反，氧化应激也发挥抗肿瘤作用，并且它与衰老和凋亡有关，这是两种对抗肿瘤发展的主要机制。在本综述中，重点介绍了将氧化应激与癌症相关情况（如慢性炎症、类固醇激素信号传导和染色体分离改变）相关联的最新发现，并讨论了这些研究如何为开发癌症预防和治疗的药物及策略确定新靶点。
