Department of Oncology, Complejo Hospitalario de Jaen, Spain.
Cancer Lett. 2012 Dec 31;327(1-2):134-41. doi: 10.1016/j.canlet.2011.12.029. Epub 2012 Jan 24.
The main pathological consequence of free radical exposure is DNA damage, which is known to induce cell transformation and to facilitate important mutations in cancer progression. It is a matter of intense discussion whether the drug-induced production of free radicals limits the therapeutic efficacy of chemotherapeutics and enhances their toxicity or whether they may be enhanced to provoke cancer cell apoptosis. This paper reviews essential molecular processes to better understand the controversial role of free radicals in cancer development and progression, and discusses some novel therapeutic strategies based on oxidative stress induction and prevention.
自由基暴露的主要病理后果是 DNA 损伤，已知其可诱导细胞转化，并促进癌症进展中的重要突变。目前激烈讨论的问题是，药物诱导产生的自由基是否会限制化疗药物的治疗效果并增加其毒性，或者是否可以增强它们以引发癌细胞凋亡。本文综述了基本的分子过程，以更好地理解自由基在癌症发展和进展中的争议性作用，并讨论了一些基于氧化应激诱导和预防的新的治疗策略。
