Wilson Hilary D, Robinson James P, Turk Dennis C
University of Washington, Seattle, WA, USA.
Arthritis Rheum. 2009 Apr 15;61(4):527-34. doi: 10.1002/art.24163.
People with fibromyalgia (FM) report a number of physical, cognitive, and psychological symptoms. The purpose of the current study was to determine whether people with FM differed based on the type and severity of symptoms, and if so, whether subgroups differ with respect to health care utilization, functional ability, and work status.
Symptom, health care utilization, work, and physical data were available for 2,182 female responders to an Internet survey. Factor analysis was conducted on the physical and cognitive/psychological symptoms, and resulting factor scores were utilized in a cluster analysis to identify subgroups based on symptoms. Cluster groups were compared on a set of variables (e.g., health care utilization, coping).
Factor analyses resulted in 3 symptom factor scores: musculoskeletal, non-musculoskeletal, and cognitive/psychological symptoms. The optimal cluster solution to the cluster analysis revealed 4 clusters. Group 1 was high on all 3 symptom domains, group 2 was moderate on the 2 physical symptom domains and high on cognitive/psychological symptoms, group 3 was moderate on the 2 physical symptom domains and low on cognitive/psychological symptoms, and group 4 was low on all symptom domains. The more symptomatic groups reported the greatest amount of health care utilization and difficulty in coping with symptoms.
The FM population is heterogeneous with regard to symptom reporting. Additional research is needed to better understand differential symptom experience among people with FM. Clarification of these differences may increase understanding of the mechanisms involved in FM and provide guidance for treatment decisions.
纤维肌痛(FM)患者报告了许多身体、认知和心理症状。本研究的目的是确定FM患者是否因症状类型和严重程度而有所不同,如果是,各亚组在医疗保健利用、功能能力和工作状态方面是否存在差异。
有2182名女性回复者参与了一项网络调查,获取了她们的症状、医疗保健利用、工作和身体数据。对身体和认知/心理症状进行了因子分析,并将所得因子得分用于聚类分析,以根据症状识别亚组。对聚类组在一组变量(如医疗保健利用、应对方式)上进行比较。
因子分析得出3个症状因子得分:肌肉骨骼症状、非肌肉骨骼症状和认知/心理症状。聚类分析的最佳聚类解决方案显示有4个聚类。第1组在所有3个症状领域得分都高,第2组在2个身体症状领域得分中等,在认知/心理症状方面得分高,第3组在2个身体症状领域得分中等,在认知/心理症状方面得分低,第4组在所有症状领域得分都低。症状较多的组报告的医疗保健利用量最大,且应对症状困难。
FM患者群体在症状报告方面存在异质性。需要进一步研究以更好地了解FM患者之间不同的症状体验。明确这些差异可能会增进对FM发病机制的理解,并为治疗决策提供指导。