Chen Ming, Liu Shenglin, Dai Zheng, Wang Yi, Liu Yi, Yu Yuan
Heart Center, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Feb;26(1):89-92.
To understand the mechanical properties of aortic artery of atheroselerosis (AS), the aortic artery of rat with AS was studied by mechanical test. Wistar rats were used for establishing the model. The mechanical measurements of opening angle in zero-stress state and the vessel loading test were conducted on the isolated aortic arteries of AS rats. Data on the stress-strain of aortic artery were obtained. Determination of percentage of collagen content was made with the use of electron microscope. The relationship between mechanical measurements and collagen concentration was evaluated. The opening angle in the group of AS was significantly smaller than that in control (87.74 degrees +/-9.67 degrees vs. 196.03 degrees +/- 27.76 degrees, P < 0.001). Significant decrease of material constants (alpha0, alpha1, alpha2, b0, b1, b2) in both long axis and radial axis was observed in AS group(campared with control, P < 0.05-0.001). Close relationship between the mechanical constants and the percentage of elastin and collagen content was observed (r = -0.7523 to -0.8423, P < 0.001). In conclusion, mechanical remodeling in aortic artery of AS might be related with histological remodeling.
为了解动脉粥样硬化（AS）大鼠主动脉的力学特性，通过力学测试对AS大鼠的主动脉进行了研究。选用Wistar大鼠建立模型。对AS大鼠的离体主动脉进行了零应力状态下开口角度的力学测量和血管加载试验，获得了主动脉应力-应变数据。利用电子显微镜测定胶原含量百分比，评估力学测量与胶原浓度之间的关系。AS组的开口角度明显小于对照组（87.74°±9.67°对196.03°±27.76°，P<0.001）。AS组在长轴和径向轴上的材料常数（α0、α1、α2、b0、b1、b2）均显著降低（与对照组相比，P<0.05-0.001）。观察到力学常数与弹性蛋白和胶原含量百分比之间存在密切关系（r=-0.7523至-0.8423，P<0.001）。总之，AS大鼠主动脉的力学重塑可能与组织学重塑有关。
