Mangnall Y F, Smythe A, Johnson A G
Scand J Gastroenterol. 1986 Sep;21(7):789-94. doi: 10.3109/00365528609011118.
Reflux of bile into the stomach may be injurious to the gastric mucosa. The ability of antacids and cholestyramine to bind bile acids is therefore potentially valuable in the treatment of reflux gastritis. The ability of antacids and cholestyramine to remove bile acids from gastric juice, hepatic bile, and solutions of commercially available bile acids was investigated in vitro over a pH range likely to occur in the stomach. The percentage of bile acids removed by antacids decreased with decreasing initial bile acid concentration and usually decreased as the incubation pH was increased from 3.6 to 7.0. Glycine-conjugated bile acids were bound to a greater extent than taurine-conjugated bile acids and dihydroxy to a greater extent than trihydroxy bile acids. Cholestyramine bound 97-100% of all bile acids in solution at pH 3.6 and pH 7.0. The effect of pH on adsorption should therefore be considered when antacids are used to treat gastritis.
胆汁反流至胃可能会损害胃黏膜。因此，抗酸剂和考来烯胺结合胆汁酸的能力在反流性胃炎的治疗中可能具有重要价值。在体外模拟胃内可能出现的pH范围内，研究了抗酸剂和考来烯胺从胃液、肝胆汁及市售胆汁酸溶液中去除胆汁酸的能力。抗酸剂去除胆汁酸的百分比随初始胆汁酸浓度降低而下降，并且通常随着孵育pH从3.6升高到7.0而降低。甘氨酸结合型胆汁酸比牛磺酸结合型胆汁酸结合程度更高，二羟基胆汁酸比三羟基胆汁酸结合程度更高。考来烯胺在pH 3.6和pH 7.0时能结合溶液中97% - 100%的所有胆汁酸。因此，在使用抗酸剂治疗胃炎时应考虑pH对吸附的影响。
