Caspary W F, Kausch H
Acta Hepatogastroenterol (Stuttg). 1978 Oct;25(5):369-75.
The effect of glycocholic acid (GCA) on functional changes of the gastric mucosal barrier was examined by measurement of transmural gastric potential difference (PD) in humans in the presence and absence of cholestyramine and of A1(OH)3-containing antacids possessing potent bile acid binding properties. Intagastric instillation of GCA induced reduction of PD which could be prevented by the more potent buffering Mg-A1(OH)3-containing antacid, but not by cholestyramine or the less potent A1(OH)3-containing antacid. It is concluded that for the prevention of bile acid induced damage of gastric mucosa potent antacids are superior to potent bile acid binding agents loosing the binding properties at low pH-values.
通过在有和没有消胆胺以及具有强效胆汁酸结合特性的含氢氧化铝抗酸剂存在的情况下，测量人体跨膜胃电位差（PD），研究了甘氨胆酸（GCA）对胃黏膜屏障功能变化的影响。胃内滴注GCA会导致PD降低，而更强效的含镁氢氧化铝抗酸剂可预防这种降低，但消胆胺或效力较弱的含氢氧化铝抗酸剂则不能。结论是，对于预防胆汁酸引起的胃黏膜损伤，强效抗酸剂优于在低pH值下会失去结合特性的强效胆汁酸结合剂。
