Hilbe Monika M, Soldati Guido G, Zlinszky Kati K, Wunderlin Sabina S, Ehrensperger Felix F
Institute of Veterinary Pathology, Zurich, Switzerland.
BMC Vet Res. 2009 Mar 31;5:11. doi: 10.1186/1746-6148-5-11.
Two domestic shorthair cats presenting with progressive hind-limb ataxia and increased aggressiveness were necropsied and a post mortem diagnosis of Feline Spongiform Encephalopathy (FSE) was made. A wide spectrum of tissue samples was collected and evaluated histologically and immunohistologically for the presence of PrPSc.
Histopathological examination revealed a diffuse vacuolation of the grey matter neuropil with the following areas being most severely affected: corpus geniculatum medialis, thalamus, gyrus dentatus of the hippocampus, corpus striatum, and deep layers of the cerebral and cerebellar cortex as well as in the brain stem. In addition, a diffuse glial reaction involving astrocytes and microglia and intraneuronal vacuolation in a few neurons in the brain stem was present.Heavy PrPSc immunostaining was detected in brain, retina, optic nerve, pars nervosa of the pituitary gland, trigeminal ganglia and small amounts in the myenteric plexus of the small intestine (duodenum, jejunum) and slightly in the medulla of the adrenal gland.
The PrPSc distribution within the brain was consistent with that described in other FSE-affected cats. The pattern of abnormal PrP in the retina corresponded to that found in a captive cheetah with FSE, in sheep with scrapie and was similar to nvCJD in humans.
对两只出现进行性后肢共济失调和攻击性增强的家养短毛猫进行了尸检，并做出了猫海绵状脑病（FSE）的死后诊断。收集了广泛的组织样本，并进行了组织学和免疫组织学评估，以检测是否存在PrPSc。
组织病理学检查显示灰质神经纤维网弥漫性空泡化，以下区域受影响最严重：内侧膝状体、丘脑、海马齿状回、纹状体、大脑和小脑皮质深层以及脑干。此外，存在涉及星形胶质细胞和小胶质细胞的弥漫性胶质反应以及脑干中少数神经元的神经元内空泡化。在脑、视网膜、视神经、垂体神经部、三叉神经节中检测到大量PrPSc免疫染色，在小肠（十二指肠、空肠）的肌间神经丛中检测到少量，在肾上腺髓质中检测到少量。
脑中PrPSc的分布与其他受FSE影响的猫中描述的一致。视网膜中异常PrP的模式与患有FSE的圈养猎豹、患有羊瘙痒病的绵羊中发现的模式一致，并且与人类新变异克雅氏病相似。
