Small J G, Small I F, Milstein V, Dian D A
Acta Psychiatr Scand. 1977 Apr;55(4):241-50. doi: 10.1111/j.1600-0447.1977.tb00169.x.
Double-blind studies of ACTH 4-10 and placebo were conducted in psychiatric patients receiving bilateral ECT to determine whether the polypeptide exerted anti-amnesic effects. Observations after a single ECT were suggestive of some positive effects, but studies between seizures after five or six ECTs showed no significant drug-placebo differences. Although the findings were largely negative, they do not rule out positive effects of ACTH 4-10 on memory. Possibly the designs and timing of the experiments and/or the dosages of ACTH 4-10 employed were unsuitable for demonstrating such influences.
对接受双侧电休克治疗的精神科患者进行了促肾上腺皮质激素4-10（ACTH 4-10）和安慰剂的双盲研究，以确定该多肽是否具有抗遗忘作用。单次电休克治疗后的观察结果提示有一些积极效果，但对五六次电休克治疗后发作间期的研究表明，药物与安慰剂之间没有显著差异。尽管研究结果大多为阴性，但它们并不排除ACTH 4-10对记忆的积极作用。可能是实验的设计和时间安排和/或所使用的ACTH 4-10剂量不适合证明这种影响。
