Parodi M Battaglia, Iacono P, Ravalico G
Eye Clinic, Azienda Ospedaliero-Universitaria di Trieste, Ospedale Maggiore, 34129, Trieste, Italy.
Br J Ophthalmol. 2009 Jun;93(6):771-4. doi: 10.1136/bjo.2008.139576. Epub 2009 Mar 30.
To describe the fundus autofluorescence (FAF) characteristics of choroidal neovascularisation (CNV) associated with pathological myopia (PM), and their modification after photodynamic therapy (PDT).
Open-label, prospective, interventional case series.
Forty-two patients affected by subfoveal CNV in PM underwent PDT with a 24-month follow-up. Each patient underwent an ophthalmological examination every 3 months, including FAF and fluorescein angiography. FAF distribution was qualitatively evaluated at the CNV site, around the CNV and outside the area affected by CNV.
CNV at baseline showed a high FAF signal with uniform distribution, or with some spots of low FAF internally, in 64% and 36% of cases, respectively. At the 3-month control after PDT, the CNV retained the same response, but a round halo of increased signal extending beyond the site of the PDT application was detectable around the CNV. At the end of the follow-up, a high or a low FAF signal was detected in 40% and 60% of cases, respectively.
CNV secondary to PM shows a specific, high signal, FAF pattern. A round halo of increased FAF signal surrounding the CNV was detectable after PDT application, whereas a FAF signal progressive reduction was visible at and around the CNV site from the sixth month. A high FAF signal at the CNV site is associated with an improved visual acuity outcome at the 2-year follow-up. Further studies to correlate the morphological and functional features are advisable, especially by means of microperimetric analyses and with a longer-term follow-up.
描述病理性近视（PM）相关脉络膜新生血管（CNV）的眼底自发荧光（FAF）特征，以及光动力疗法（PDT）后其变化情况。
开放标签、前瞻性、干预性病例系列。
42例PM伴黄斑下CNV患者接受PDT治疗并随访24个月。每位患者每3个月进行一次眼科检查，包括FAF和荧光素血管造影。对CNV部位、CNV周围及CNV影响区域以外的FAF分布进行定性评估。
基线时，CNV分别在64%和36%的病例中表现为高FAF信号且分布均匀，或内部有一些低FAF斑点。PDT后3个月复查时，CNV保持相同反应，但在CNV周围可检测到一个超出PDT应用部位的信号增强的圆形光晕。随访结束时，分别在40%和60%的病例中检测到高或低FAF信号。
PM继发的CNV表现出特定的高信号FAF模式。PDT应用后，CNV周围可检测到FAF信号增强的圆形光晕，而从第6个月起，CNV部位及其周围可见FAF信号逐渐降低。CNV部位的高FAF信号与2年随访时较好的视力结果相关。建议进行进一步研究以关联形态学和功能特征，特别是通过微视野分析并进行更长时间的随访。
