Parodi Maurizio Battaglia, Liberali Tatiana, Pedio Marcella, Francis Peter J, Piccolino Felice Cardillo, Fiotti Nicola, Romano Maurizio, Ravalico Giuseppe
Eye Clinic, Ospedale Maggiore, Azienda Ospedaliero-Universitaria di Trieste, Italy.
Am J Ophthalmol. 2006 Jun;141(6):1152-4. doi: 10.1016/j.ajo.2006.01.038.
To investigate the effects of photodynamic therapy (PDT) on subfoveal choroidal neovascularization (CNV) secondary to reticular pattern dystrophy (RPD) of the retinal pigment epithelium.
Open-label, prospective, interventional case series.
Thirteen eyes diagnosed with subfoveal CNV associated with RPD were considered. Complete ophthalmic examinations were performed at baseline and thereafter at three-month intervals for three years. Primary outcome measure was the number of eyes with <15 letters loss (approximately <3 lines) at 12, 24, and 36 months, compared with baseline. Secondary outcome measures included CNV progression and number of PDT sessions.
Seven eyes showed a decrease in best-corrected visual acuity of at least three lines at three-year examination. Each eye received a median number of treatments of two, zero, and zero in years one, two, and three, respectively.
PDT does not appear to guarantee long-term vision stabilization in RPD-related subfoveal CNV, and alternative therapies should be investigated.
探讨光动力疗法（PDT）对继发于视网膜色素上皮网状营养不良（RPD）的黄斑下脉络膜新生血管（CNV）的影响。
开放标签、前瞻性、介入性病例系列研究。
纳入13只诊断为与RPD相关的黄斑下CNV的眼睛。在基线时进行全面的眼科检查，此后每三个月进行一次检查，持续三年。主要观察指标是与基线相比，在12个月、24个月和36个月时视力下降<15个字母（约<3行）的眼睛数量。次要观察指标包括CNV进展和PDT治疗次数。
在三年检查时，7只眼睛的最佳矫正视力下降至少3行。每只眼睛在第一年、第二年和第三年接受的治疗次数中位数分别为2次、0次和0次以上。
PDT似乎不能保证RPD相关黄斑下CNV的长期视力稳定，应研究其他替代疗法。
