脂质体包裹阿糖胞苷治疗淋巴瘤性和白血病性脑膜炎
Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine.
作者信息
Kripp Melanie, Hofheinz Ralf-Dieter
机构信息
Onkologisches Zentrum, III Medizinische Klinik, Medizinische Fakultät Mannheim der Universität, Heidelberg, Germany.
出版信息
Int J Nanomedicine. 2008;3(4):397-401. doi: 10.2147/ijn.s3259.
Abstract
Liposomal encapsulated cytarabine (DepoCyte, Mundipharma GmbH, Limburg/Lahn, Germany) is a slow-release formulation of conventional cytarabine. It is licensed for intrathecal use in patients with lymphomatous and leukemic meningitis. DepoCyte obtained superior response rates, improved patient quality of life and improved the time to neurological progression in a randomized albeit small clinical trial. In this review we briefly summarize the clinical data and discuss them in light of clinical problems and possible treatment scenarios.
摘要
脂质体包裹的阿糖胞苷（DepoCyte，德国林堡/兰恩的萌蒂制药有限公司）是传统阿糖胞苷的缓释制剂。它被批准用于鞘内注射治疗淋巴瘤性和白血病性脑膜炎患者。在一项随机但规模较小的临床试验中，DepoCyte获得了更高的缓解率，改善了患者生活质量，并延长了神经功能进展时间。在本综述中，我们简要总结临床数据，并根据临床问题和可能的治疗方案进行讨论。
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