Suppr超能文献

脂质体包裹阿糖胞苷治疗淋巴瘤性和白血病性脑膜炎

Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine.

作者信息

Kripp Melanie, Hofheinz Ralf-Dieter

机构信息

Onkologisches Zentrum, III Medizinische Klinik, Medizinische Fakultät Mannheim der Universität, Heidelberg, Germany.

出版信息

Int J Nanomedicine. 2008;3(4):397-401. doi: 10.2147/ijn.s3259.

Abstract

Liposomal encapsulated cytarabine (DepoCyte, Mundipharma GmbH, Limburg/Lahn, Germany) is a slow-release formulation of conventional cytarabine. It is licensed for intrathecal use in patients with lymphomatous and leukemic meningitis. DepoCyte obtained superior response rates, improved patient quality of life and improved the time to neurological progression in a randomized albeit small clinical trial. In this review we briefly summarize the clinical data and discuss them in light of clinical problems and possible treatment scenarios.

摘要

脂质体包裹的阿糖胞苷(DepoCyte,德国林堡/兰恩的萌蒂制药有限公司)是传统阿糖胞苷的缓释制剂。它被批准用于鞘内注射治疗淋巴瘤性和白血病性脑膜炎患者。在一项随机但规模较小的临床试验中,DepoCyte获得了更高的缓解率,改善了患者生活质量,并延长了神经功能进展时间。在本综述中,我们简要总结临床数据,并根据临床问题和可能的治疗方案进行讨论。

相似文献

2
Liposomal cytarabine for leukemic and lymphomatous meningitis: recent developments.
Expert Opin Pharmacother. 2008 Feb;9(2):301-9. doi: 10.1517/14656566.9.2.301.
7

引用本文的文献

2
Nanomedicinal products: a survey on specific toxicity and side effects.纳米医药产品:特定毒性和副作用调查
Int J Nanomedicine. 2017 Aug 22;12:6107-6129. doi: 10.2147/IJN.S139687. eCollection 2017.

本文引用的文献

2
Liposomal cytarabine for leukemic and lymphomatous meningitis: recent developments.
Expert Opin Pharmacother. 2008 Feb;9(2):301-9. doi: 10.1517/14656566.9.2.301.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验