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J Neurooncol. 2011 Jul;103(3):635-40. doi: 10.1007/s11060-010-0435-y. Epub 2010 Oct 17.

本文引用的文献

1
Safety and tolerability of intrathecal liposomal cytarabine as central nervous system prophylaxis in patients with acute lymphoblastic leukemia.鞘内注射脂质体阿糖胞苷作为急性淋巴细胞白血病患者中枢神经系统预防用药的安全性和耐受性
Leuk Lymphoma. 2014 Aug;55(8):1739-42. doi: 10.3109/10428194.2013.853765. Epub 2013 Nov 25.
2
Liposomal cytarabine for leukemic and lymphomatous meningitis: recent developments.
Expert Opin Pharmacother. 2008 Feb;9(2):301-9. doi: 10.1517/14656566.9.2.301.
3
Intrathecal liposomal cytarabine for prevention of meningeal disease in patients with acute lymphocytic leukemia and high-grade lymphoma.鞘内注射脂质体阿糖胞苷预防急性淋巴细胞白血病和高级别淋巴瘤患者的脑膜疾病。
Leuk Lymphoma. 2007 Sep;48(9):1849-51. doi: 10.1080/10428190701573232.
4
Toward optimal use of intrathecal liposomal cytarabine.迈向鞘内注射脂质体阿糖胞苷的最佳使用
Leuk Lymphoma. 2007 Sep;48(9):1672-3. doi: 10.1080/10428190701573687.
5
Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy.脂质体阿糖胞苷用于治疗伊马替尼治疗期间发生的慢性髓性白血病髓系中枢神经系统复发。
Eur J Clin Invest. 2007 Oct;37(10):808-13. doi: 10.1111/j.1365-2362.2007.01859.x. Epub 2007 Aug 28.
6
Re: Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.回复：关于在急性淋巴细胞白血病患者中预防性给予鞘内脂质体阿糖胞苷联合大剂量甲氨蝶呤和阿糖胞苷相关的神经系统并发症。
Blood. 2007 Sep 1;110(5):1698; author reply 1698-9. doi: 10.1182/blood-2007-02-073536.
7
Results of compassionate therapy with intrathecal depot liposomal cytarabine in acute myeloid leukemia meningeosis.鞘内注射长效脂质体阿糖胞苷治疗急性髓性白血病脑膜浸润的同情用药治疗结果
Int J Hematol. 2007 Jul;86(1):33-6. doi: 10.1532/IJH97.E0704.
8
CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies.脑脊液流式细胞术极大地提高了中枢神经系统血液系统恶性肿瘤的诊断准确性。
Neurology. 2007 May 15;68(20):1674-9. doi: 10.1212/01.wnl.0000261909.28915.83.
9
Feasibility and toxicity of intrathecal liposomal cytarabine in 5 children and young adults with refractory neoplastic meningitis.鞘内注射脂质体阿糖胞苷治疗5例难治性肿瘤性脑膜炎儿童和青年的可行性及毒性
J Pediatr Hematol Oncol. 2007 Apr;29(4):222-6. doi: 10.1097/MPH.0b013e318041f112.
10
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.对于急性淋巴细胞白血病患者，预防性给予鞘内注射脂质体阿糖胞苷联合大剂量甲氨蝶呤和阿糖胞苷时出现的神经系统并发症。
Blood. 2007 Apr 15;109(8):3214-8. doi: 10.1182/blood-2006-08-043646. Epub 2007 Jan 5.

脂质体包裹阿糖胞苷治疗淋巴瘤性和白血病性脑膜炎

Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine.

作者信息

Kripp Melanie, Hofheinz Ralf-Dieter

机构信息

Onkologisches Zentrum, III Medizinische Klinik, Medizinische Fakultät Mannheim der Universität, Heidelberg, Germany.

出版信息

Int J Nanomedicine. 2008;3(4):397-401. doi: 10.2147/ijn.s3259.

DOI:10.2147/ijn.s3259
PMID:19337408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2636580/
Abstract

Liposomal encapsulated cytarabine (DepoCyte, Mundipharma GmbH, Limburg/Lahn, Germany) is a slow-release formulation of conventional cytarabine. It is licensed for intrathecal use in patients with lymphomatous and leukemic meningitis. DepoCyte obtained superior response rates, improved patient quality of life and improved the time to neurological progression in a randomized albeit small clinical trial. In this review we briefly summarize the clinical data and discuss them in light of clinical problems and possible treatment scenarios.

摘要

脂质体包裹的阿糖胞苷（DepoCyte，德国林堡/兰恩的萌蒂制药有限公司）是传统阿糖胞苷的缓释制剂。它被批准用于鞘内注射治疗淋巴瘤性和白血病性脑膜炎患者。在一项随机但规模较小的临床试验中，DepoCyte获得了更高的缓解率，改善了患者生活质量，并延长了神经功能进展时间。在本综述中，我们简要总结临床数据，并根据临床问题和可能的治疗方案进行讨论。