Alan Lyell Centre for Dermatology, Western Infirmary, Glasgow, UK.
Ther Clin Risk Manag. 2008 Dec;4(6):1165-76. doi: 10.2147/tcrm.s3094.
Psoriasis is a chronic, immune mediated inflammatory disease characterized by increased cell signalling via cytokines and chemokines on a background of up-regulated gene expression. There is substantial evidence that psoriasis should be regarded as more than a cutaneous disease; major psychological morbidity and increased mortality from cardiovascular disease and cancer are increasingly recognized. Improved understanding of the genetic and immunological mechanisms underpinning psoriasis has occurred concurrently with the development of targeted biological therapies including infliximab. These newer therapeutic approaches can be very effective but their long term safety profile is not yet fully determined.
银屑病是一种慢性、免疫介导的炎症性疾病，其特征是细胞因子和趋化因子信号的增加，以及基因表达的上调。有大量证据表明，银屑病不仅仅是一种皮肤疾病；人们越来越认识到，它还会导致严重的心理障碍，以及心血管疾病和癌症死亡率的增加。随着针对生物疗法（包括英夫利昔单抗）的发展，人们对银屑病的遗传和免疫机制有了更深入的了解。这些新的治疗方法可能非常有效，但它们的长期安全性尚未完全确定。
